Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.71 |
| ▸ | PIK3CD | O00329 | 15/20 | 0.71 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.71 |
| ▸ | PIK3CB | P42338 | 15/20 | 0.71 |
| ▸ | PIK3CG | P48736 | 15/20 | 0.71 |
| ▸ | PRKDC | P78527 | 15/20 | 0.71 |
| ▸ | EGFR | P00533 | 15/20 | 0.71 |
| ▸ | ABL1 | P00519 | 14/20 | 0.71 |
| ▸ | HCK | P08631 | 14/20 | 0.71 |
| ▸ | SRC | P12931 | 14/20 | 0.71 |
| ▸ | MTOR | P42345 | 14/20 | 0.71 |
| ▸ | EPHB4 | P54760 | 14/20 | 0.71 |
| ▸ | PI4KB | Q9UBF8 | 10/20 | 0.71 |
| ▸ | RET | P07949 | 3/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
| ▸ | BTK | Q06187 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1318998 | 1.00 | KDR (0.71) | KDRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1319895 | 1.00 | KDR (0.71) | KDRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL24096496 | 0.93 | PIK3CD (0.61) | KDRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL13020092 | 0.91 | KDR (0.74) | KDRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL13020103 | 0.91 | KDR (0.74) | KDRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL23997323 | 0.90 | PIK3CD (0.58) | KDRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL23997146 | 0.86 | BTK (0.65) | KDRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1320199 | 0.86 | KDR (0.63) | KDRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1321276 | 0.86 | KDR (0.63) | KDRPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1320201 | 0.86 | KDR (0.63) | KDRPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116583287-A | Pyridazinone heterocyclic compound, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2023-08-11 | — | — | CN | disclosed |
| US-20230210853-A1 | TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME | Halia Therapeutics, Inc. | 2023-07-06 | — | — | US | disclosed |
| US-20230210853-A1 | TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME | Halia Therapeutics, Inc. | 2023-07-06 | — | — | US | disclosed |
| US-20230203045-A1 | INHIBITORS OF NEK7 KINASE | Halia Therapeutics, Inc. | 2023-06-29 | — | — | US | disclosed |
| US-20230203045-A1 | INHIBITORS OF NEK7 KINASE | Halia Therapeutics, Inc. | 2023-06-29 | — | — | US | disclosed |
| CN-116075513-A | Inhibitors of NEK7 kinase | 哈利亚治疗公司 | 2023-05-05 | — | — | CN | disclosed |
| EP-4161933-A1 | INHIBITORS OF NEK7 KINASE | Halia Therapeutics, Inc. (US) | 2023-04-12 | — | — | EP | disclosed |
| WO-2022166610-A1 | PYRIDAZINONE HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-08-11 | — | — | WO | disclosed |
| WO-2021252488-A1 | INHIBITORS OF NEK7 KINASE | Halia Therapeutics, Inc. (US) | 2021-12-16 | — | — | WO | disclosed |
| EP-2358720-B1 | FUSED RING HETEROARYL KINASE INHIBITORS | UNIV CALIFORNIA (US) | 2016-03-02 | — | — | EP | disclosed |
| US-8980899-B2 | Methods of inhibiting Ire1 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-03-17 | — | — | US | disclosed |
| US-8697709-B2 | Fused ring heteroaryl kinase inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-04-15 | — | — | US | disclosed |
| US-20120322814-A1 | METHODS OF INHIBITING IRE1 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-12-20 | — | — | US | disclosed |
| US-20110275651-A1 | FUSED RING HETEROARYL KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203045-A1 | INHIBITORS OF NEK7 KINASE | NEK7, NEK1, NEK5 | KDR 4072/4885PIK3CD 1435/4885PIK3CA 908/4885 |
| US-20120322814-A1 | METHODS OF INHIBITING IRE1 | XBP1, DNAJC10, HSPA5 | KDR 4859/4885PIK3CD 2956/4885PIK3CA 3212/4885 |
| US-20230210853-A1 | TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME | NEK7, NLRP3, NOD1 | KDR 4751/4885PIK3CD 3373/4885PIK3CA 3263/4885 |
| US-20110275651-A1 | FUSED RING HETEROARYL KINASE INHIBITORS | CNKSR1, MAP3K20, TTK | KDR 837/4885PIK3CD 276/4885PIK3CA 269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.