Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2965348 | 0.77 | L3MBTL1 (0.63) | L3MBTL1CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL13190827 | 0.76 | L3MBTL1 (0.65) | L3MBTL1CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL13125679 | 0.73 | MEN1 (0.46) | MEN1KMT2APTGER4LMNAHTT | |
| SCHEMBL6178516 | 0.73 | PTGER4 (0.50) | L3MBTL1CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL6178518 | 0.73 | PTGER4 (0.50) | L3MBTL1CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL359171 | 0.70 | CYP1A2 (0.68) | L3MBTL1CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL2808948 | 0.66 | PTGER4 (0.50) | MEN1KMT2AMAPTPTGER4LMNA | |
| SCHEMBL2967362 | 0.66 | MAPT (0.72) | L3MBTL1CYP1A2CYP2C9CYP2C19CYP3A4 | |
| SCHEMBL13418351 | 0.66 | S1PR3 (0.49) | MEN1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL2962039 | 0.66 | USP2 (0.63) | L3MBTL1CYP1A2CYP2C9CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010108059-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AS ANTAGONISTS OF THE HISTAMINE H4 RECEPTOR | INCYTE CORPORATION (US) | 2010-09-23 | — | — | WO | disclosed |