Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | PDE5A | O76074 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | EGFR | P00533 | 4/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.58 |
| ▸ | CNR1 | P21554 | 2/20 | 0.57 |
| ▸ | CNR2 | P34972 | 1/20 | 0.57 |
| ▸ | USP10 | Q14694 | 1/20 | 0.57 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.57 |
| ▸ | USP13 | Q92995 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.56 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.56 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9921508 | 0.90 | HTT (0.74) | HTTSMN1; SMN2MEN1PDE5AALDH1A1 | |
| SCHEMBL9921364 | 0.87 | LMNA (0.72) | HTTSMN1; SMN2MEN1PDE5AALDH1A1 | |
| SCHEMBL13192081 | 0.85 | HTT (0.64) | HTTSMN1; SMN2MEN1PDE5AALDH1A1 | |
| SCHEMBL13192093 | 0.85 | EGFR (0.67) | HTTSMN1; SMN2MEN1PDE5AALDH1A1 | |
| SCHEMBL13192092 | 0.84 | CNR1 (0.78) | HTTSMN1; SMN2MEN1PDE5AALDH1A1 | |
| SCHEMBL7500991 | 0.82 | PDE5A (0.67) | HTTSMN1; SMN2MEN1PDE5AALDH1A1 | |
| SCHEMBL9921356 | 0.81 | MEN1 (0.65) | HTTSMN1; SMN2MEN1PDE5AALDH1A1 | |
| SCHEMBL8862837 | 0.80 | PDE5A (0.64) | HTTSMN1; SMN2MEN1PDE5AALDH1A1 | |
| SCHEMBL13191864 | 0.80 | EGFR (0.61) | HTTSMN1; SMN2MEN1PDE5AALDH1A1 | |
| SCHEMBL9921504 | 0.80 | EGFR (0.67) | HTTSMN1; SMN2MEN1PDE5AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (CN) | 2012-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | ATG7, BECN1, SQSTM1 | HTT 4078/4885SMN1; SMN2 3442/4885MEN1 2998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.