Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MYC | P01106 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | LDHB | P07195 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HNF4A | P41235 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3108743 | 0.83 | ALDH1A1 (0.46) | ALDH1A1HPGDSMN1; SMN2L3MBTL1MYC | |
| SCHEMBL5046158 | 0.78 | MYC (0.59) | PTGER1ALDH1A1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL1319714 | 0.77 | KDM4E (0.51) | ALDH1A1HPGDPOLBMYCKDM4E | |
| SCHEMBL6440453 | 0.75 | HSD17B10 (0.53) | PTGER1ALDH1A1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL13504677 | 0.73 | ALDH1A1 (0.55) | PTGER1ALDH1A1HPGDPOLBSMN1; SMN2 | |
| SCHEMBL13504679 | 0.72 | HNF4A (0.50) | PTGER1ALDH1A1HPGDPOLBSMN1; SMN2 | |
| Benzene SCHEMBL27265959 | 0.72 | TSHR (0.61) | ALDH1A1HPGDPOLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL756585 | 0.72 | TSHR (0.61) | ALDH1A1HPGDPOLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL27703149 | 0.72 | TSHR (0.61) | ALDH1A1HPGDPOLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL3716970 | 0.72 | MYC (0.61) | PTGER1ALDH1A1HPGDPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376426-B2 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2016-06-28 | — | — | US | disclosed |
| US-8853211-B2 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2014-10-07 | — | — | US | disclosed |
| US-20140148463-A1 | PYRIDAZINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-05-29 | — | — | US | disclosed |
| US-20110269765-A1 | Pyridazinone derivatives | MERCK PATENT GMBH (DE) | 2011-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140148463-A1 | PYRIDAZINONE DERIVATIVES | MET, RET, ERBB2 | PTGER1 845/4885ALDH1A1 919/4885HPGD 2214/4885 |
| US-20110269765-A1 | Pyridazinone derivatives | MET, RET, ERBB2 | PTGER1 845/4885ALDH1A1 919/4885HPGD 2214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.