Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | ELANE | P08246 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13199110 | 0.90 | KDM4E (0.55) | MEN1KMT2APOLBALDH1A1KDM4E | |
| SCHEMBL13199201 | 0.87 | NPC1 (0.55) | NPC1RAB9ANLRP3MEN1KMT2A | |
| SCHEMBL13199231 | 0.87 | TDP1 (0.62) | MEN1KMT2APOLBALDH1A1KDM4E | |
| SCHEMBL13199195 | 0.86 | ALDH1A1 (0.58) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL13199232 | 0.86 | NLRP3 (0.55) | NPC1RAB9ANLRP3MEN1KMT2A | |
| SCHEMBL13199160 | 0.86 | TDP1 (0.55) | NPC1RAB9ANLRP3MEN1KMT2A | |
| SCHEMBL13199129 | 0.85 | ALDH1A1 (0.57) | NPC1RAB9ATP53NLRP3MEN1 | |
| SCHEMBL13199217 | 0.84 | ALDH1A1 (0.53) | NPC1RAB9AMAPK1NLRP3MEN1 | |
| SCHEMBL13199235 | 0.84 | KDM4E (0.50) | MAPK1NLRP3MEN1KMT2APOLB | |
| SCHEMBL14098304 | 0.84 | KMT2A (0.57) | NPC1RAB9AMAPK1NLRP3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767716-B2 | Acyl hydrazines as kinase inhibitors, in particular for SGK | MERCK PATENT GMBH (DE) | 2010-08-03 | — | — | US | disclosed |
| US-7767716-B2 | Acyl hydrazines as kinase inhibitors, in particular for SGK | MERCK PATENT GMBH (DE) | 2010-08-03 | — | — | US | disclosed |
| EP-1866280-B1 | ACYL HYDRAZIDES AS KINASE INHIBITORS, IN PARTICULAR FOR SGK | MERCK PATENT GMBH (DE) | 2008-08-13 | — | — | EP | disclosed |
| US-20080167380-A1 | Acyl Hydrazines as Kinase Inhibitors, in Particular for Sgk | MERCK PATENT GMBH (DE) | 2008-07-10 | — | — | US | disclosed |
| US-20080167380-A1 | Acyl Hydrazines as Kinase Inhibitors, in Particular for Sgk | MERCK PATENT GMBH (DE) | 2008-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167380-A1 | Acyl Hydrazines as Kinase Inhibitors, in Particular for Sgk | SGK1, AGK, SGK2 | NPC1 2228/4885RAB9A 1168/4885TP53 4760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.