Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.48 |
| ▸ | ENPP1 | P22413 | 9/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.37 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.37 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
| ▸ | UNG | P13051 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12775794 | 0.89 | PDE3B (0.59) | PDE3BPDE3AENPP1 | |
| SCHEMBL12775783 | 0.83 | PDE3B (0.57) | PDE3BPDE3AENPP1 | |
| SCHEMBL13199873 | 0.79 | ENPP1 (0.40) | PDE3BPDE3AENPP1 | |
| SCHEMBL21715896 | 0.76 | TTBK1 (0.45) | GPR84 | |
| SCHEMBL27020416 | 0.76 | TTBK1 (0.45) | GPR84 | |
| SCHEMBL13199882 | 0.73 | PDE3B (0.37) | PDE3BPDE3AENPP1 | |
| SCHEMBL10813106 | 0.72 | PDE3B (0.83) | PDE3BPDE3AGPR84 | |
| SCHEMBL2015028 | 0.71 | PDE3B (0.53) | PDE3BPDE3AENPP1 | |
| SCHEMBL23326745 | 0.69 | ENPP1 (0.44) | PDE3BPDE3AENPP1PI4KAPI4K2B | |
| SCHEMBL24671871 | 0.68 | ENPP1 (0.42) | PDE3BPDE3AENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767687-B2 | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors | BIOGEN IDEC MA INC. (US) | 2010-08-03 | — | — | US | disclosed |