Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 15/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13199870 | 0.79 | PDE3B (0.48) | ENPP1PDE3BPDE3A | |
| SCHEMBL12775783 | 0.73 | PDE3B (0.57) | ENPP1PDE3BPDE3AENPP3 | |
| SCHEMBL12775877 | 0.68 | ENPP1 (0.39) | ENPP1ENPP3NPC1RAB9A | |
| SCHEMBL12776683 | 0.66 | PDE3B (0.58) | ENPP1PDE3BPDE3AENPP3 | |
| SCHEMBL2015028 | 0.65 | PDE3B (0.53) | ENPP1PDE3BPDE3AENPP3 | |
| SCHEMBL13199882 | 0.65 | PDE3B (0.37) | ENPP1PDE3BPDE3AENPP3NPC1 | |
| SCHEMBL12776514 | 0.64 | ENPP1 (0.41) | ENPP1PDE3BPDE3AENPP3 | |
| SCHEMBL23326745 | 0.63 | ENPP1 (0.44) | ENPP1PDE3BPDE3AENPP3 | |
| SCHEMBL24671871 | 0.63 | ENPP1 (0.42) | ENPP1PDE3BPDE3AENPP3 | |
| SCHEMBL7034638 | 0.63 | ALOX5 (0.53) | MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767687-B2 | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors | BIOGEN IDEC MA INC. (US) | 2010-08-03 | — | — | US | disclosed |