Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 15/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30556397 | 1.00 | ENPP1 (0.42) | ENPP1PDE3BPDE3AENPP3MEN1 | |
| SCHEMBL2015028 | 0.78 | PDE3B (0.53) | ENPP1PDE3BPDE3AENPP3 | |
| SCHEMBL12776514 | 0.77 | ENPP1 (0.41) | ENPP1PDE3BPDE3AENPP3 | |
| SCHEMBL23326564 | 0.76 | DYRK1A (0.38) | PDE3BPDE3AKMT2A | |
| SCHEMBL23326745 | 0.76 | ENPP1 (0.44) | ENPP1PDE3BPDE3AENPP3 | |
| SCHEMBL30696421 | 0.75 | MAT2A (0.35) | PDE3BPDE3AKMT2A | |
| SCHEMBL1085687 | 0.74 | TRPA1 (0.60) | — | |
| SCHEMBL4184377 | 0.74 | ENPP1 (0.43) | ENPP1PDE3BPDE3AENPP3 | |
| SCHEMBL12775783 | 0.74 | PDE3B (0.57) | ENPP1PDE3BPDE3AENPP3 | |
| SCHEMBL20894034 | 0.73 | MEN1 (0.41) | MEN1KMT2APDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116669738-A | Pyrimidopyridone derivative as SOS1 inhibitor, and preparation method and application thereof | 苏州阿尔脉生物科技有限公司 | 2023-08-29 | — | — | CN | disclosed |
| WO-2022170802-A1 | PYRIMIDO-PYRIDONE DERIVATIVE AS SOS1 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 苏州阿尔脉生物科技有限公司 | 2022-08-18 | — | — | WO | disclosed |
| WO-2022170802-A1 | PYRIMIDO-PYRIDONE DERIVATIVE AS SOS1 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 苏州阿尔脉生物科技有限公司 | 2022-08-18 | — | — | WO | disclosed |