Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.53 |
| ▸ | F2R | P25116 | 1/20 | 0.50 |
| ▸ | ACR | P10323 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | SMO | Q99835 | 5/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13199940 | 0.85 | FLT3 (0.65) | FLT3RAB9ANPC1MEN1KMT2A | |
| SCHEMBL13199938 | 0.84 | FLT3 (0.55) | FLT3SMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL13200022 | 0.83 | FLT3 (0.56) | FLT3SMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL13200028 | 0.83 | FLT3 (0.51) | FLT3SMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL13234691 | 0.81 | FLT3 (0.71) | FLT3RAB9ANPC1MEN1KMT2A | |
| SCHEMBL13200627 | 0.81 | FLT3 (0.48) | FLT3SMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL13200197 | 0.81 | FLT3 (0.70) | FLT3RAB9ANPC1MEN1KMT2A | |
| SCHEMBL13200080 | 0.80 | FLT3 (0.48) | FLT3RAB9ANPC1MEN1KMT2A | |
| SCHEMBL13200035 | 0.80 | FLT3 (0.69) | FLT3SMN1; SMN2RAB9ANPC1MEN1 | |
| SCHEMBL13200134 | 0.80 | FLT3 (0.49) | FLT3SMN1; SMN2RAB9ANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |