Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 11/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200022 | 0.91 | FLT3 (0.56) | FLT3SMN1; SMN2ALDH1A1MAPK1KDM4E | |
| SCHEMBL13199938 | 0.88 | FLT3 (0.55) | FLT3SMN1; SMN2ALDH1A1MAPK1MEN1 | |
| SCHEMBL13200599 | 0.85 | FLT3 (0.57) | FLT3SMN1; SMN2ALDH1A1MEN1NPC1 | |
| SCHEMBL13200027 | 0.83 | FLT3 (0.53) | FLT3SMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL13199940 | 0.82 | FLT3 (0.65) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13200085 | 0.82 | FLT3 (0.51) | FLT3SMN1; SMN2CSF1RRAF1 | |
| SCHEMBL13200035 | 0.82 | FLT3 (0.69) | FLT3SMN1; SMN2KDM4EMEN1NPC1 | |
| SCHEMBL13234699 | 0.81 | FLT3 (0.74) | FLT3MEN1NPC1RAB9AKMT2A | |
| SCHEMBL13200134 | 0.80 | FLT3 (0.49) | FLT3SMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL13200157 | 0.79 | FLT3 (0.51) | FLT3MAPK1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |