Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 9/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234831 | 0.83 | FLT3 (0.64) | FLT3MEN1KMT2ANPC1RAB9A | |
| SCHEMBL13200027 | 0.80 | FLT3 (0.53) | FLT3MEN1KMT2AHTTMAPT | |
| SCHEMBL13199940 | 0.80 | FLT3 (0.65) | FLT3MEN1KMT2AHTTMAPT | |
| SCHEMBL13200197 | 0.76 | FLT3 (0.70) | FLT3MEN1KMT2ANPC1RAB9A | |
| SCHEMBL13200035 | 0.75 | FLT3 (0.69) | FLT3MEN1KMT2AMAPTNPC1 | |
| SCHEMBL13199938 | 0.75 | FLT3 (0.55) | FLT3MEN1KMT2AHTTMAPT | |
| SCHEMBL13200599 | 0.74 | FLT3 (0.57) | FLT3MEN1KMT2AHTTMAPT | |
| SCHEMBL13200526 | 0.74 | RAF1 (0.67) | FLT3MEN1KMT2ANPC1RAB9A | |
| SCHEMBL13200022 | 0.74 | FLT3 (0.56) | FLT3MEN1KMT2AMAPTNPC1 | |
| SCHEMBL13200028 | 0.74 | FLT3 (0.51) | FLT3MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |