Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.61 |
| ▸ | RET | P07949 | 13/20 | 0.61 |
| ▸ | KDR | P35968 | 4/20 | 0.61 |
| ▸ | CSF1R | P07333 | 2/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.61 |
| ▸ | KIT | P10721 | 2/20 | 0.61 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.61 |
| ▸ | FLT3 | P36888 | 6/20 | 0.59 |
| ▸ | AURKA | O14965 | 2/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | CDK11B | P21127 | 1/20 | 0.55 |
| ▸ | CCNC | P24863 | 1/20 | 0.55 |
| ▸ | FLT4 | P35916 | 1/20 | 0.55 |
| ▸ | CDK8 | P49336 | 1/20 | 0.55 |
| ▸ | BTK | Q06187 | 1/20 | 0.55 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200059 | 0.90 | RET (0.52) | RETKDRCSF1RPDGFRBKIT | |
| SCHEMBL9978891 | 0.87 | FLT3 (0.55) | EGFRRETKDRCSF1RPDGFRB | |
| SCHEMBL13234602 | 0.86 | RET (0.79) | RETKDRCSF1RPDGFRBKIT | |
| SCHEMBL13200076 | 0.85 | RET (0.49) | EGFRRETKDRCSF1RPDGFRB | |
| SCHEMBL13200475 | 0.84 | FLT3 (0.56) | RETKDRCSF1RPDGFRBKIT | |
| SCHEMBL17443422 | 0.82 | RET (0.73) | RETKDRCSF1RPDGFRBKIT | |
| SCHEMBL1256284 | 0.81 | EGFR (0.56) | EGFRRETKDRCSF1RPDGFRB | |
| SCHEMBL1256158 | 0.81 | EGFR (0.56) | EGFRRETKDRCSF1RPDGFRB | |
| SCHEMBL1600174 | 0.81 | MAPK14 (0.61) | EGFRRETKDRCSF1RPDGFRB | |
| SCHEMBL17447646 | 0.81 | RET (0.62) | RETKDRCSF1RPDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |