Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 2/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 9/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | ACACB | O00763 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.46 |
| ▸ | GLS | O94925 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234617 | 0.86 | FLT3 (0.69) | FLT3EPHX2MAPK13MAPK9MAPK12 | |
| SCHEMBL13200082 | 0.84 | EGFR (0.61) | FLT3EPHX2CSF1RRETPDGFRB | |
| SCHEMBL1257375 | 0.80 | POLB (0.44) | FLT3KDR | |
| SCHEMBL14680013 | 0.80 | FLT3 (0.42) | FLT3EPHX2SMN1; SMN2 | |
| SCHEMBL13200803 | 0.79 | KMT2A (0.61) | MAPK14SMN1; SMN2RETKDM4EALDH1A1 | |
| SCHEMBL14673703 | 0.78 | POLB (0.42) | FLT3CSF1RRETKDR | |
| SCHEMBL2961183 | 0.77 | MAPK14 (0.47) | FLT3MAPK14SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL13200487 | 0.77 | ALDH1A1 (0.45) | FLT3MAPK13MAPK14SMN1; SMN2RET | |
| SCHEMBL13200489 | 0.77 | CNR2 (0.50) | MAPK14RETKDM4EALDH1A1 | |
| SCHEMBL1255965 | 0.75 | KDR (0.43) | EPHX2RETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |