Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 8/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 3/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234604 | 0.86 | RET (0.60) | RETFLT3KDRCSF1RPDGFRB | |
| SCHEMBL13200082 | 0.85 | EGFR (0.61) | RETFLT3KDRCSF1RPDGFRB | |
| SCHEMBL13200059 | 0.84 | RET (0.52) | RETCCNA2CDK2CCNA1FLT3 | |
| SCHEMBL13200102 | 0.79 | RET (0.57) | RETFLT3NTRK1KDM4EKDR | |
| SCHEMBL13200081 | 0.79 | TBXAS1 (0.57) | RETFLT3 | |
| SCHEMBL13200562 | 0.79 | RET (0.53) | RETFLT3NTRK1KDM4EKDR | |
| SCHEMBL13200112 | 0.78 | ALDH1A1 (0.54) | RETFLT3NTRK1KDM4EALDH1A1 | |
| SCHEMBL13200595 | 0.77 | RET (0.52) | RETFLT3NTRK1KDM4EROCK1 | |
| SCHEMBL13199934 | 0.77 | KDM4E (0.71) | RETKMT2AFLT3NTRK1KDM4E | |
| SCHEMBL13200145 | 0.76 | RAF1 (0.53) | RETFLT3NTRK1KDM4EKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |