Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 9/20 | 0.52 |
| ▸ | KDR | P35968 | 4/20 | 0.52 |
| ▸ | CSF1R | P07333 | 2/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 9/20 | 0.51 |
| ▸ | AURKA | O14965 | 2/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | CDK11B | P21127 | 1/20 | 0.48 |
| ▸ | CCNC | P24863 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200082 | 0.90 | EGFR (0.61) | RETKDRCSF1RPDGFRBKIT | |
| SCHEMBL13234614 | 0.87 | RET (0.66) | RETKDRCSF1RPDGFRBKIT | |
| SCHEMBL13200076 | 0.84 | RET (0.49) | RETKDRCSF1RPDGFRBKIT | |
| SCHEMBL13200081 | 0.80 | TBXAS1 (0.57) | RETFLT3 | |
| SCHEMBL13200102 | 0.80 | RET (0.57) | RETKDRCSF1RFLT3NTRK1 | |
| SCHEMBL13200112 | 0.79 | ALDH1A1 (0.54) | RETKDRCSF1RFLT3NTRK1 | |
| SCHEMBL13234610 | 0.78 | FLT3 (0.72) | RETKDRCSF1RPDGFRBKIT | |
| SCHEMBL9978891 | 0.78 | FLT3 (0.55) | RETKDRCSF1RPDGFRBKIT | |
| SCHEMBL13199934 | 0.78 | KDM4E (0.71) | RETFLT3NTRK1 | |
| SCHEMBL13200562 | 0.77 | RET (0.53) | RETKDRCSF1RFLT3NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |