Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 14/20 | 0.51 |
| ▸ | CSF1R | P07333 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.43 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200599 | 0.87 | FLT3 (0.57) | FLT3CSF1RSMN1; SMN2RAF1 | |
| SCHEMBL13200022 | 0.84 | FLT3 (0.56) | FLT3SMN1; SMN2RAF1 | |
| SCHEMBL13200157 | 0.83 | FLT3 (0.51) | FLT3CSF1RRETPDGFRBKIT | |
| SCHEMBL13234828 | 0.82 | FLT3 (0.73) | FLT3CSF1RRETPDGFRBKIT | |
| SCHEMBL13200028 | 0.82 | FLT3 (0.51) | FLT3CSF1RSMN1; SMN2RAF1 | |
| SCHEMBL13200035 | 0.81 | FLT3 (0.69) | FLT3CSF1RSMN1; SMN2RETPDGFRB | |
| SCHEMBL13200308 | 0.80 | FLT3 (0.56) | FLT3CSF1RSMN1; SMN2RETPDGFRB | |
| SCHEMBL13199940 | 0.79 | FLT3 (0.65) | FLT3RAF1 | |
| SCHEMBL13200182 | 0.79 | FLT3 (0.50) | FLT3RETRAF1 | |
| SCHEMBL13200573 | 0.79 | FLT3 (0.50) | FLT3RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |