Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 12/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | CSF1R | P07333 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200022 | 0.90 | FLT3 (0.56) | FLT3NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL13200085 | 0.87 | FLT3 (0.51) | FLT3CSF1RSMN1; SMN2RAF1 | |
| SCHEMBL13200028 | 0.85 | FLT3 (0.51) | FLT3NPC1RAB9ACSF1RSMN1; SMN2 | |
| SCHEMBL13200035 | 0.85 | FLT3 (0.69) | FLT3NPC1RAB9ACSF1RSMN1; SMN2 | |
| SCHEMBL13200615 | 0.84 | FLT3 (0.62) | FLT3CSF1RRAF1 | |
| SCHEMBL13200573 | 0.84 | FLT3 (0.50) | FLT3NPC1RAB9ALMNARAF1 | |
| SCHEMBL13199940 | 0.83 | FLT3 (0.65) | FLT3NPC1RAB9ARAF1HTT | |
| SCHEMBL13200182 | 0.82 | FLT3 (0.50) | FLT3NPC1RAB9ARAF1NAMPT | |
| SCHEMBL13199938 | 0.82 | FLT3 (0.55) | FLT3NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL13200157 | 0.80 | FLT3 (0.51) | FLT3CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |