Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15422289 | 0.86 | ALDH1A1 (0.53) | NPSR1NPC1RAB9ASMN1; SMN2HTR2C | |
| SCHEMBL15422089 | 0.86 | ALDH1A1 (0.53) | NPSR1NPC1RAB9ASMN1; SMN2HTR2C | |
| SCHEMBL19278897 | 0.86 | ALDH1A1 (0.53) | NPSR1NPC1RAB9ASMN1; SMN2HTR2C | |
| SCHEMBL15431220 | 0.86 | ALDH1A1 (0.53) | NPSR1NPC1RAB9ASMN1; SMN2HTR2C | |
| SCHEMBL10242881 | 0.86 | SMN1; SMN2 (0.58) | NPC1RAB9ASMN1; SMN2HTR2CALDH1A1 | |
| SCHEMBL1320776 | 0.86 | SMN1; SMN2 (0.58) | NPC1RAB9ASMN1; SMN2HTR2CALDH1A1 | |
| SCHEMBL1317704 | 0.86 | SMN1; SMN2 (0.58) | NPC1RAB9ASMN1; SMN2HTR2CALDH1A1 | |
| SCHEMBL2444107 | 0.86 | SMN1; SMN2 (0.58) | NPC1RAB9ASMN1; SMN2HTR2CALDH1A1 | |
| SCHEMBL14630640 | 0.86 | SMN1; SMN2 (0.58) | NPC1RAB9ASMN1; SMN2HTR2CALDH1A1 | |
| SCHEMBL10189895 | 0.86 | SMN1; SMN2 (0.58) | NPC1RAB9ASMN1; SMN2HTR2CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-08-05 | — | — | EP | disclosed |
| US-8697685-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2014-04-15 | — | — | US | disclosed |
| US-20110275611-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2011-11-10 | — | — | US | disclosed |
| US-20110275611-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2011-11-10 | — | — | US | disclosed |
| US-20110275611-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2011-11-10 | — | — | US | disclosed |
| WO-2010059658-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275611-A1 | CHEMICAL COMPOUNDS | PDK1, PDK2, PDK3 | KDM4E 167/4885LMNA 4686/4885ENPP2 1683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.