Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 6/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13199934 | 0.83 | KDM4E (0.71) | RAF1KDM4EFLT3RETNTRK1 | |
| SCHEMBL12066000 | 0.80 | FLT3 (0.57) | RAF1KDM4EFLT3RETCSF1R | |
| SCHEMBL6451843 | 0.79 | POLB (0.60) | KDM4EMAPTHSD17B10HPGDALDH1A1 | |
| SCHEMBL13234750 | 0.78 | FLT3 (0.58) | RAF1FLT3RETKMT2AMEN1 | |
| SCHEMBL13200166 | 0.77 | FLT3 (0.55) | RAF1KDM4EFLT3RETNTRK1 | |
| SCHEMBL13200719 | 0.76 | FLT3 (0.52) | FLT3RETNTRK1ROCK1POLB | |
| SCHEMBL13200522 | 0.75 | FLT3 (0.69) | FLT3RETNTRK1ROCK1KMT2A | |
| SCHEMBL13200037 | 0.74 | FLT3 (0.73) | RAF1FLT3RETNTRK1ROCK1 | |
| SCHEMBL13200259 | 0.74 | LMNA (0.54) | RAF1FLT3RETNTRK1ROCK1 | |
| SCHEMBL13200373 | 0.74 | FLT3 (0.58) | RAF1FLT3RETNTRK1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |