Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 6/20 | 0.57 |
| ▸ | RET | P07949 | 8/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.49 |
| ▸ | CSF1R | P07333 | 3/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234678 | 0.87 | FLT3 (0.62) | FLT3RETCSF1RRAF1RAB9A | |
| SCHEMBL13200615 | 0.81 | FLT3 (0.62) | FLT3RETNTRK1CSF1RRAF1 | |
| SCHEMBL13200187 | 0.80 | FLT3 (0.54) | FLT3RETNTRK1CSF1RROCK1 | |
| SCHEMBL13200037 | 0.79 | FLT3 (0.73) | FLT3RETNTRK1ROCK1RAF1 | |
| SCHEMBL4425426 | 0.79 | NPSR1 (0.59) | MAPTMAPK1NPSR1GALR3RAB9A | |
| SCHEMBL13200041 | 0.79 | FLT3 (0.62) | FLT3RETNTRK1ROCK1RAF1 | |
| SCHEMBL13199933 | 0.78 | GAPDH (0.71) | FLT3RETNTRK1ROCK1RAF1 | |
| SCHEMBL13200277 | 0.78 | LMNA (0.56) | FLT3RETNTRK1CSF1RROCK1 | |
| SCHEMBL13200061 | 0.78 | FLT3 (0.61) | FLT3RETNTRK1MAPK1RAF1 | |
| SCHEMBL13200153 | 0.77 | FLT3 (0.58) | FLT3RETNTRK1CSF1RROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |