Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 14/20 | 0.63 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200212 | 0.90 | RET (0.61) | RETNTRK1EGFRAURKAMAP4K4 | |
| SCHEMBL13200210 | 0.88 | RET (0.74) | RETNTRK1EGFRAURKAMAP4K4 | |
| SCHEMBL13234896 | 0.87 | NTRK1 (0.54) | RETNTRK1CSF1RAURKBFLT3 | |
| SCHEMBL9978507 | 0.77 | FLT3 (0.62) | RETNTRK1EGFRAURKAMAP4K4 | |
| SCHEMBL13234895 | 0.76 | NTRK1 (0.54) | RETNTRK1CSF1RAURKBFLT3 | |
| SCHEMBL13200317 | 0.75 | RET (0.58) | RETNTRK1EGFRAURKAMAP4K4 | |
| SCHEMBL13234898 | 0.75 | NTRK1 (0.64) | RETNTRK1CSF1RAURKBFLT3 | |
| SCHEMBL1256784 | 0.73 | RET (0.63) | RETNTRK1EGFRAURKAMAP4K4 | |
| SCHEMBL13200780 | 0.72 | FLT3 (0.63) | RETNTRK1EGFRCSF1RFLT3 | |
| SCHEMBL13199933 | 0.72 | GAPDH (0.71) | RETNTRK1EGFRFLT3ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |