Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 13/20 | 0.58 |
| ▸ | FLT3 | P36888 | 1/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | GAPDH | P04406 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13234900 | 0.85 | MAPK14 (0.61) | FLT3CSF1RKDRRAF1 | |
| SCHEMBL9978507 | 0.80 | FLT3 (0.62) | RETFLT3NTRK1EGFRAURKA | |
| SCHEMBL13199933 | 0.79 | GAPDH (0.71) | RETFLT3NTRK1EGFRROCK1 | |
| SCHEMBL13199999 | 0.78 | FLT3 (0.60) | RETFLT3NTRK1EGFRCSF1R | |
| SCHEMBL13200480 | 0.77 | FLT3 (0.48) | RETFLT3NTRK1EGFRKDR | |
| SCHEMBL1256935 | 0.77 | RET (0.54) | RETFLT3NTRK1EGFRAURKA | |
| SCHEMBL13200780 | 0.77 | FLT3 (0.63) | RETFLT3NTRK1EGFRCSF1R | |
| SCHEMBL13200570 | 0.76 | FLT3 (0.60) | RETFLT3NTRK1EGFRROCK1 | |
| SCHEMBL13234883 | 0.76 | MAPK14 (0.62) | FLT3KDRRAF1 | |
| SCHEMBL13200011 | 0.76 | RET (0.57) | RETFLT3NTRK1EGFRAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |