Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.53 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 3/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11274542 | 0.76 | MAPT (0.58) | ATRL3MBTL1GBA1MAPTKMT2A | |
| SCHEMBL27039672 | 0.75 | LMNA (0.45) | CES1CES2AKR1B1L3MBTL1MAPT | |
| SCHEMBL29601755 | 0.75 | LMNA (0.45) | CES1CES2AKR1B1L3MBTL1MAPT | |
| Bromide SCHEMBL29601637 | 0.73 | LMNA (0.44) | CES1CES2AKR1B1L3MBTL1MAPT | |
| SCHEMBL27846984 | 0.73 | RAB9A (0.59) | CES1CES2AKR1B1MAPTKMT2A | |
| Bromide SCHEMBL27040139 | 0.73 | LMNA (0.44) | CES1CES2AKR1B1L3MBTL1MAPT | |
| SCHEMBL8567354 | 0.73 | HTT (0.40) | CES1CES2L3MBTL1MAPTKMT2A | |
| SCHEMBL21586307 | 0.73 | RAB9A (0.63) | ATRGRM5L3MBTL1KMT2A | |
| SCHEMBL30504303 | 0.73 | ATR (0.57) | ATRGRM5L3MBTL1GBA1MAPT | |
| SCHEMBL5682288 | 0.73 | ATR (0.57) | ATRGRM5L3MBTL1GBA1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |