Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CTSA | P10619 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27039672 | 1.00 | LMNA (0.45) | LMNASMN1; SMN2HPGDMAPTKDM4E | |
| Bromide SCHEMBL27040139 | 0.98 | LMNA (0.44) | LMNASMN1; SMN2HPGDMAPTKDM4E | |
| Bromide SCHEMBL29601637 | 0.98 | LMNA (0.44) | LMNASMN1; SMN2HPGDMAPTKDM4E | |
| SCHEMBL5312789 | 0.79 | BRD4 (0.43) | SMN1; SMN2HPGDMAPTKDM4ECYP1A2 | |
| SCHEMBL15988730 | 0.79 | CTNNB1 (0.60) | LMNASMN1; SMN2MAPTCYP1A2POLB | |
| SCHEMBL29601119 | 0.77 | RAB9A (0.41) | SMN1; SMN2MAPTKDM4ECYP1A2CTSA | |
| SCHEMBL3701074 | 0.77 | RAB9A (0.41) | SMN1; SMN2MAPTKDM4ECYP1A2CTSA | |
| SCHEMBL2479225 | 0.77 | CTNNB1 (0.49) | SMN1; SMN2MAPTKDM4ECYP1A2CTNNB1 | |
| SCHEMBL3958929 | 0.76 | KMT2A (0.61) | SMN1; SMN2MAPTKDM4EPOLBGAA | |
| SCHEMBL20201222 | 0.76 | POLB (0.57) | LMNASMN1; SMN2HPGDMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232449-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | Celgene Corporation (US) | 2023-08-30 | — | — | EP | disclosed |
| CN-116547282-A | Heterocyclic compounds and their use for the treatment of helminth infections and diseases | 新基公司 | 2023-08-04 | — | — | CN | disclosed |
| WO-2022087326-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CELGENE CORPORATION (US) | 2022-04-28 | — | — | WO | disclosed |