Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 11/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.62 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.62 |
| ▸ | PRKDC | P78527 | 11/20 | 0.62 |
| ▸ | EGFR | P00533 | 11/20 | 0.62 |
| ▸ | ABL1 | P00519 | 9/20 | 0.62 |
| ▸ | HCK | P08631 | 9/20 | 0.62 |
| ▸ | SRC | P12931 | 9/20 | 0.62 |
| ▸ | MTOR | P42345 | 9/20 | 0.62 |
| ▸ | EPHB4 | P54760 | 9/20 | 0.62 |
| ▸ | KDR | P35968 | 8/20 | 0.62 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.54 |
| ▸ | IGF1R | P08069 | 7/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.49 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.48 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13201507 | 0.86 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL130528 | 0.77 | PIK3CD (0.62) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL129826 | 0.77 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL130423 | 0.77 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL12162 | 0.76 | PIK3CD (0.74) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL23917478 | 0.74 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL129497 | 0.74 | PIK3CD (0.83) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL13201532 | 0.74 | PIK3CD (0.70) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL12608279 | 0.73 | SRC (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL12551789 | 0.73 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772231-B2 | Substituted pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors | ABBOTT LABORATORIES (US) | 2010-08-10 | — | — | US | disclosed |
| US-20070203143-A1 | PROTEIN KINASE INHIBITORS | ABBVIE INC. | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203143-A1 | PROTEIN KINASE INHIBITORS | PACSIN2, MAP3K20, PHKG1 | PIK3CD 264/4885PIK3CA 139/4885PIK3CB 155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.