Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.65 |
| ▸ | PIK3CA | P42336 | 17/20 | 0.65 |
| ▸ | PIK3CB | P42338 | 17/20 | 0.65 |
| ▸ | PIK3CG | P48736 | 17/20 | 0.65 |
| ▸ | PRKDC | P78527 | 17/20 | 0.65 |
| ▸ | ABL1 | P00519 | 15/20 | 0.65 |
| ▸ | EGFR | P00533 | 15/20 | 0.65 |
| ▸ | HCK | P08631 | 15/20 | 0.65 |
| ▸ | SRC | P12931 | 15/20 | 0.65 |
| ▸ | MTOR | P42345 | 15/20 | 0.65 |
| ▸ | EPHB4 | P54760 | 15/20 | 0.65 |
| ▸ | KDR | P35968 | 14/20 | 0.65 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.60 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.51 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL130528 | 0.91 | PIK3CD (0.62) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL13201514 | 0.86 | PIK3CD (0.62) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL16655801 | 0.80 | PIK3CD (0.66) | PIK3CDEGFR | |
| SCHEMBL130423 | 0.79 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL12162 | 0.78 | PIK3CD (0.74) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL130513 | 0.78 | SRC (0.79) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL13828403 | 0.77 | BMPR1B (0.64) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL129811 | 0.77 | PIK3CD (0.63) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL129501 | 0.77 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL23997199 | 0.77 | SRC (0.73) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7772231-B2 | Substituted pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors | ABBOTT LABORATORIES (US) | 2010-08-10 | — | — | US | disclosed |
| US-20070203143-A1 | PROTEIN KINASE INHIBITORS | ABBVIE INC. | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203143-A1 | PROTEIN KINASE INHIBITORS | PACSIN2, MAP3K20, PHKG1 | PIK3CD 264/4885PIK3CA 139/4885PIK3CB 155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.