SCHEMBL13201629

SCHEMBL13201629

CC(C)C(=O)COc1ccc(Cl)c(Cl)c1

nearest known ligand 0.59

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.52
PKM P14618 1/20 0.52
KMT2A Q03164 1/20 0.52
MCL1 Q07820 1/20 0.51
ALDH1A1 P00352 3/20 0.50
KDM4E B2RXH2 3/20 0.50
LMNA P02545 1/20 0.50
MRGPRX4 Q96LA9 1/20 0.44
GRIN1 Q05586 1/20 0.44
GRIN2B Q13224 1/20 0.44
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
SIGMAR1 Q99720 1/20 0.43
PPARG P37231 1/20 0.43
PPARA Q07869 1/20 0.43
ATM Q13315 1/20 0.43
SCN9A Q15858 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21100162 0.82 ALDH1A1 (0.50) ALDH1A1KDM4ELMNARAB9A
SCHEMBL10636547 0.81 PTGS2 (0.51) MEN1KMT2AALDH1A1KDM4ELMNA
SCHEMBL1269571 0.81 MCL1 (0.56) MEN1PKMKMT2AMCL1ALDH1A1
SCHEMBL7413146 0.79 MCL1 (0.53) MEN1PKMKMT2AMCL1ALDH1A1
SCHEMBL29689485 0.79 MCL1 (0.53) MEN1PKMKMT2AMCL1ALDH1A1
SCHEMBL118785 0.79 MCL1 (0.72) KMT2AMCL1ALDH1A1KDM4ELMNA
SCHEMBL29540672 0.79 MCL1 (0.72) KMT2AMCL1ALDH1A1KDM4ELMNA
SCHEMBL30087171 0.78 LMNA (0.60) MEN1PKMKMT2AMCL1ALDH1A1
Acetic Acid SCHEMBL28287287 0.78 MCL1 (0.71) MCL1ALDH1A1KDM4ELMNAMRGPRX4
SCHEMBL20226166 0.78 MAOB (0.53) MEN1KMT2ANPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7767818-B2 Hepatitis C inhibitor dipeptide analogs BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2010-08-03 US disclosed
US-20090156822-A1 Hepatitis C Inhibitor Dipeptide Analogs BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-06-18 US disclosed
US-7511157-B2 racemic mixtures, stereoisomers or optical isomers, useful as protease inhibitors; viricides BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-03-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090156822-A1 Hepatitis C Inhibitor Dipeptide Analogs DPP3, CTSC, ANPEP MEN1 3216/4885PKM 3450/4885KMT2A 3349/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.