Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2393871 | 0.86 | CYP1A2 (0.47) | CYP1A2ALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL12775479 | 0.83 | KDM4E (0.46) | ALDH1A1MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL9423071 | 0.80 | CYP1A2 (0.55) | CYP1A2ALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL17595275 | 0.78 | CYP1A2 (0.58) | CYP1A2ALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL11642670 | 0.78 | CYP1A2 (0.53) | CYP1A2ALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL16506338 | 0.77 | CYP1A2 (0.51) | CYP1A2ALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL20579411 | 0.75 | CYP1A2 (0.46) | CYP1A2ALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL5010959 | 0.74 | MAPT (0.58) | CYP1A2ALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL12141972 | 0.74 | CYP1A2 (0.49) | CYP1A2ALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL19530471 | 0.73 | HTR2A (0.36) | ALDH1A1MAPTSMN1; SMN2MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100197657-A1 | 2-ARYL OR HETEROARYL INDOLE DERIVATIVES | CHANG RONALD K | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197657-A1 | 2-ARYL OR HETEROARYL INDOLE DERIVATIVES | ASIC1, ASIC3, TRPV1 | CYP1A2 1795/4885ALDH1A1 2506/4885MEN1 3322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.