Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2909376 | 0.82 | HSD17B10 (0.41) | MAPTHSD17B10HSPB1S1PR1ALDH1A1 | |
| SCHEMBL2904917 | 0.76 | ALDH1A1 (0.39) | MAPTHSD17B10ALDH1A1TDP1TNKS | |
| SCHEMBL2913015 | 0.76 | RAB9A (0.38) | MAPTHSD17B10HSPB1S1PR1ALDH1A1 | |
| SCHEMBL13349695 | 0.76 | TNKS (0.37) | MAPTALDH1A1TNKSTNKS2ERN1 | |
| SCHEMBL6320483 | 0.72 | ALDH1A1 (0.53) | MAPTHSD17B10ALDH1A1TDP1RAB9A | |
| SCHEMBL27539548 | 0.72 | PTPRC (0.49) | MAPTHSD17B10HSPB1ALDH1A1TDP1 | |
| SCHEMBL38652225 | 0.72 | SLC6A4 (0.44) | MAPTHSD17B10ALDH1A1TDP1RAB9A | |
| SCHEMBL29655079 | 0.72 | TDP1 (0.64) | MAPTHSPB1ALDH1A1TDP1RAB9A | |
| SCHEMBL14601019 | 0.72 | TSHR (0.52) | MAPTHSD17B10HSPB1ALDH1A1TNKS | |
| SCHEMBL719169 | 0.72 | TDP1 (0.64) | MAPTHSPB1ALDH1A1TDP1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931641-B1 | NOVEL 4-CYANO, 4-AMINO, AND 4-AMINOMETHYL DERIVATIVES OF PYRAZOLO[1,5-a]PYRIDINES, PYRAZOLO[1,5-c]PYRIMIDINES AND 2H-INDAZOLE COMPOUNDS AND 5-CYANO, 5-AMINO, AND 5-AMINOMETHYL DERIVATIVES OF IMIDAZO[1,2-a]PYRIDINES, AND IMIDAZO[1,5-a]PYRAZINES COMPOUNDS AS CYCLIN DEPENDENT KINASE INHI | SCHERING CORP (US) | 2010-08-25 | — | — | EP | disclosed |