Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 18/20 | 0.80 |
| ▸ | MEN1 | O00255 | 6/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.80 |
| ▸ | CASP1 | P29466 | 3/20 | 0.80 |
| ▸ | CASP7 | P55210 | 3/20 | 0.80 |
| ▸ | HBB | P68871 | 3/20 | 0.80 |
| ▸ | MAPT | P10636 | 3/20 | 0.80 |
| ▸ | USP2 | O75604 | 2/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.80 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.80 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.80 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.80 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.80 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.80 |
| ▸ | TOP2A | P11388 | 1/20 | 0.80 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.80 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25396064 | 1.00 | TOP1 (0.80) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL21410039 | 0.92 | TOP1 (0.77) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL27170416 | 0.90 | TOP1 (0.81) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL6599316 | 0.89 | TOP1 (0.85) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL16214743 | 0.89 | TOP1 (0.80) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL18251452 | 0.89 | TOP1 (0.80) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL27603460 | 0.89 | TOP1 (0.85) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| Topotecan SCHEMBL3836 | 0.89 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| Topotecan SCHEMBL14577671 | 0.89 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| Topotecan SCHEMBL9971346 | 0.89 | TOP1 (1.00) | TOP1MEN1KMT2ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2727927-B1 | CAMPTOTHECIN DERIVATIVE, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITION AND USE THEREOF | ZHOU WENQIANG (CN) | 2016-07-20 | — | — | EP | disclosed |
| US-9266911-B2 | Camptothecin derivative, and preparation method thereof, and pharmaceutical composition and application | HUNAN FANGSHENGHUAMEI MEDICAL TECH. CO. LTD. (CN) | 2016-02-23 | — | — | US | disclosed |
| US-9266911-B2 | Camptothecin derivative, and preparation method thereof, and pharmaceutical composition and application | HUNAN FANGSHENGHUAMEI MEDICAL TECH. CO. LTD. (CN) | 2016-02-23 | — | — | US | disclosed |
| EP-2727927-A1 | CAMPTOTHECIN DERIVATIVE, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITION AND USE THEREOF | Zhou, Wenqiang (CN) | 2014-05-07 | — | — | EP | disclosed |
| US-20140107342-A1 | CAMPTOTHECIN DERIVATIVE, AND PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION AND APPLICATION | HUNAN FANGSHENGHUAMEI MEDICAL TECH. CO. LTD. (CN) | 2014-04-17 | — | — | US | disclosed |
| US-20140107342-A1 | CAMPTOTHECIN DERIVATIVE, AND PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION AND APPLICATION | HUNAN FANGSHENGHUAMEI MEDICAL TECH. CO. LTD. (CN) | 2014-04-17 | — | — | US | disclosed |
| US-20100210677-A1 | NOVEL COMPOUND, CORRESPONDING COMPOSITIONS, PREPARATION AND/OR TREATMENT METHODS | NOVARTIS AG (CH) | 2010-08-19 | — | — | US | disclosed |
| US-20100210677-A1 | NOVEL COMPOUND, CORRESPONDING COMPOSITIONS, PREPARATION AND/OR TREATMENT METHODS | NOVARTIS AG (CH) | 2010-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140107342-A1 | CAMPTOTHECIN DERIVATIVE, AND PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION AND APPLICATION | CA2, F12, CCND2 | TOP1 115/4885MEN1 108/4885KMT2A 2047/4885 |
| US-20100210677-A1 | NOVEL COMPOUND, CORRESPONDING COMPOSITIONS, PREPARATION AND/OR TREATMENT METHODS | TOP2A, TOP1, TOP2B | TOP1 2/4885MEN1 756/4885KMT2A 617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.