Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 6/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 6/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.36 |
| ▸ | RELA | Q04206 | 2/20 | 0.36 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13217613 | 0.83 | GRM5 (0.54) | TGFBR1SMN1; SMN2HSD17B10NPC1RAB9A | |
| SCHEMBL13218220 | 0.80 | OGA (0.46) | TGFBR1SMN1; SMN2HSD17B10NPC1RAB9A | |
| SCHEMBL13218217 | 0.74 | GRM5 (0.51) | NPC1RAB9AGRM5MEN1KMT2A | |
| SCHEMBL13218227 | 0.73 | NPC1 (0.42) | TGFBR1SMN1; SMN2HSD17B10NPC1RAB9A | |
| SCHEMBL13218221 | 0.72 | GRM5 (0.57) | SMN1; SMN2HSD17B10GRM5 | |
| SCHEMBL6313419 | 0.72 | GRM5 (0.66) | SMN1; SMN2NPC1RAB9AGRM5MEN1 | |
| SCHEMBL13238172 | 0.71 | TGFBR1 (0.55) | TGFBR1SMN1; SMN2HSD17B10NPC1RAB9A | |
| SCHEMBL13218229 | 0.68 | SMN1; SMN2 (0.38) | SMN1; SMN2HSD17B10NPC1RAB9AGRM5 | |
| SCHEMBL13218187 | 0.68 | KMT2A (0.49) | TGFBR1SMN1; SMN2HSD17B10NPC1RAB9A | |
| SCHEMBL10300112 | 0.68 | ACACB (0.52) | SMN1; SMN2GRM5LMNAACACBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216787-A1 | THIAZOLE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2010-08-26 | — | — | US | disclosed |
| US-7678810-B2 | Thiazole derivative | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2010-03-16 | — | — | US | disclosed |
| US-20070154428-A1 | Thiazole derivative | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216787-A1 | THIAZOLE DERIVATIVE | TGFBR1, TGFBR2, SMAD3 | TGFBR1 1/4885SMN1; SMN2 4805/4885HSD17B10 1212/4885 |
| US-20070154428-A1 | Thiazole derivative | TGFBR1, TGFBR2, SMAD3 | TGFBR1 1/4885SMN1; SMN2 4805/4885HSD17B10 1212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.