Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | OGA | O60502 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CLK3 | P49761 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13217613 | 0.74 | GRM5 (0.54) | GRM5NPC1RAB9AOGACLK4 | |
| SCHEMBL13218219 | 0.74 | TGFBR1 (0.39) | GRM5NPC1RAB9AACACBALDH1A1 | |
| SCHEMBL13218220 | 0.71 | OGA (0.46) | GRM5NPC1RAB9AOGACLK4 | |
| SCHEMBL15870993 | 0.71 | GRM5 (0.68) | GRM5ACACBALDH1A1PDE10AHAO1 | |
| SCHEMBL4747174 | 0.69 | GRM5 (0.68) | GRM5NPC1RAB9AACACBALDH1A1 | |
| SCHEMBL6313587 | 0.69 | GRM5 (0.68) | GRM5NPC1RAB9ACYP1A2CYP1A1 | |
| SCHEMBL30006592 | 0.69 | CYP3A4 (0.42) | NPC1RAB9AALDH1A1MAPK1MAPT | |
| SCHEMBL6818293 | 0.69 | CYP3A4 (0.42) | NPC1RAB9AALDH1A1MAPK1MAPT | |
| SCHEMBL30278513 | 0.69 | GRM5 (0.68) | GRM5NPC1RAB9AACACBPKM | |
| SCHEMBL6609887 | 0.69 | CYP1A2 (0.53) | NPC1RAB9ARXFP1CYP1A2CYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216787-A1 | THIAZOLE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2010-08-26 | — | — | US | disclosed |
| US-7678810-B2 | Thiazole derivative | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2010-03-16 | — | — | US | disclosed |
| US-20070154428-A1 | Thiazole derivative | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216787-A1 | THIAZOLE DERIVATIVE | TGFBR1, TGFBR2, SMAD3 | GRM5 136/4885NPC1 3033/4885RAB9A 4841/4885 |
| US-20070154428-A1 | Thiazole derivative | TGFBR1, TGFBR2, SMAD3 | GRM5 136/4885NPC1 3033/4885RAB9A 4841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.