Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.72 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.72 |
| ▸ | HSPB1 | P04792 | 5/20 | 0.68 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TTR | P02766 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.49 |
| ▸ | ABAT | P80404 | 1/20 | 0.49 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.49 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13220970 | 0.86 | ALDH1A1 (0.70) | CRHBPCRHR2HSPB1MAPTALDH1A1 | |
| SCHEMBL6157958 | 0.85 | MAPT (0.67) | CRHBPCRHR2HSPB1MAPTALDH1A1 | |
| SCHEMBL1341548 | 0.85 | HSPB1 (0.79) | CRHBPCRHR2HSPB1MAPTALDH1A1 | |
| SCHEMBL13220974 | 0.84 | HSPB1 (0.68) | CRHBPCRHR2HSPB1MAPTALDH1A1 | |
| SCHEMBL13220948 | 0.82 | ALDH1A1 (0.61) | CRHBPCRHR2HSPB1MAPTALDH1A1 | |
| SCHEMBL29159284 | 0.81 | MAPT (0.73) | CRHBPCRHR2HSPB1MAPTALDH1A1 | |
| SCHEMBL13220955 | 0.80 | PDE7A (0.70) | CRHBPCRHR2HSPB1MAPTALDH1A1 | |
| SCHEMBL4319388 | 0.80 | ALDH1A1 (0.54) | CRHBPCRHR2MAPTALDH1A1MEN1 | |
| SCHEMBL7971986 | 0.79 | HPGD (0.53) | CRHBPCRHR2HSPB1MAPTALDH1A1 | |
| SCHEMBL30816847 | 0.79 | ALDH1A1 (0.51) | CRHBPCRHR2HSPB1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216762-A1 | Agonists and Antagonists of the S1P5 Receptor, and Methods of Use Thereof | ABBOTT LABORATORIES (US) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216762-A1 | Agonists and Antagonists of the S1P5 Receptor, and Methods of Use Thereof | S1PR5, LPAR5, S1PR1 | CRHBP 1514/4885CRHR2 332/4885HSPB1 4544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.