Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27705659 | 0.83 | MAPT (0.73) | HPGDL3MBTL1ALDH1A1MAPTLMNA | |
| SCHEMBL30159245 | 0.83 | MAPT (0.73) | HPGDL3MBTL1ALDH1A1MAPTLMNA | |
| SCHEMBL238962 | 0.83 | L3MBTL1 (0.62) | HPGDL3MBTL1ALDH1A1MAPTKMT2A | |
| SCHEMBL8543520 | 0.83 | MAPT (0.50) | HPGDALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL1283885 | 0.81 | HSPB1 (0.67) | HPGDL3MBTL1ALDH1A1MAPTLMNA | |
| 2,4'-Oxybis(Nitrobenzene) SCHEMBL9474586 | 0.81 | HSPB1 (0.62) | HPGDL3MBTL1ALDH1A1MAPTLMNA | |
| SCHEMBL6750951 | 0.81 | L3MBTL1 (0.57) | HPGDL3MBTL1ALDH1A1MAPTKMT2A | |
| SCHEMBL6157958 | 0.81 | MAPT (0.67) | HPGDL3MBTL1ALDH1A1MAPTLMNA | |
| SCHEMBL8311249 | 0.80 | TTR (0.58) | L3MBTL1ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL29159284 | 0.80 | MAPT (0.73) | HPGDL3MBTL1ALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251928-B1 | ADMINISTERING BENZYLIDENE RHODANINES WHICH ARE USEFUL AS AGENTS IN TREATING OR PREVENTING CONDITIONS ASSOCIATED WITH BETA-AMYLOID PEPTIDE IN A MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| US-5747517-A | ALZHEIMER'S DISEASE; PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-05-05 | — | — | US | disclosed |
| EP-0677517-A1 | Treatment of Alzheimer's disease employing inhibitors of cathepsin D | ELI LILLY AND COMPANY (US) | 1995-10-18 | — | — | EP | disclosed |