Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 2/20 | 0.61 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.50 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.50 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.50 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.50 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.50 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.50 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.50 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.50 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.50 |
| ▸ | PSMA5 | P28066 | 2/20 | 0.50 |
| ▸ | PSMB4 | P28070 | 2/20 | 0.50 |
| ▸ | PSMB6 | P28072 | 2/20 | 0.50 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.50 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22667768 | 0.93 | TP53 (0.55) | CYP1A1GAAMAPTTP53L3MBTL1 | |
| SCHEMBL9123188 | 0.86 | POLB (0.64) | GAATP53MEN1ALDH1A1KMT2A | |
| SCHEMBL24590187 | 0.86 | HDAC3 (0.58) | GAAMAPTTP53MEN1ALDH1A1 | |
| SCHEMBL12926858 | 0.84 | NPC1 (0.56) | TRPV1MAPTMEN1KMT2ANR1H4 | |
| SCHEMBL9157833 | 0.84 | MAPT (0.60) | GAAMAPTL3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL24590189 | 0.83 | EPHX2 (0.58) | TRPV1L3MBTL1MEN1ALDH1A1CYP3A4 | |
| SCHEMBL27937384 | 0.82 | CYP1A1 (0.84) | CYP1A1TRPV1GAAMAPTTP53 | |
| SCHEMBL5649258 | 0.81 | RAB9A (0.67) | CYP1A1TRPV1GAAMAPTTP53 | |
| SCHEMBL18997650 | 0.81 | RAB9A (0.60) | GAAMAPTTP53MEN1ALDH1A1 | |
| SCHEMBL1948604 | 0.81 | LMNA (0.47) | GAAMAPTTP53L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7750151-B2 | Inhibitors of Akt activity | MERCK SHARP & DOHME CORP. (US) | 2010-07-06 | — | — | US | disclosed |
| US-20080280899-A1 | Inhibitors of Akt Activity | MERCK SHARP & DOHME CORP. | 2008-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280899-A1 | Inhibitors of Akt Activity | AKT1, AKT2, AKT3 | CYP1A1 4324/4885TRPV1 4224/4885GAA 1588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.