Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.47 |
| ▸ | GAPDH | P04406 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 3/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200823 | 0.85 | CNR2 (0.53) | ALDH1A1MAPK14GAPDHCNR2SMN1; SMN2 | |
| SCHEMBL1257126 | 0.85 | ALDH1A1 (0.53) | ALDH1A1MAPK14GAPDHCNR2RAF1 | |
| SCHEMBL13199941 | 0.85 | MAPK14 (0.65) | ALDH1A1MAPK14GAPDHCNR2 | |
| SCHEMBL26870527 | 0.84 | SMN1; SMN2 (0.56) | ALDH1A1GAPDHROCK2ROCK1SMN1; SMN2 | |
| SCHEMBL13200803 | 0.83 | KMT2A (0.61) | ALDH1A1MAPK14CNR2RAF1KMT2A | |
| SCHEMBL13200489 | 0.81 | CNR2 (0.50) | ALDH1A1MAPK14GAPDHCNR2RAF1 | |
| SCHEMBL13234440 | 0.80 | MAPK14 (0.73) | ALDH1A1MAPK14RAF1MAPK13RET | |
| SCHEMBL1256126 | 0.78 | ALDH1A1 (0.46) | ALDH1A1MAPK14GAPDHCNR2RAF1 | |
| SCHEMBL1257251 | 0.78 | ALDH1A1 (0.48) | ALDH1A1MAPK14GAPDHCNR2KMT2A | |
| SCHEMBL13200487 | 0.78 | ALDH1A1 (0.45) | ALDH1A1MAPK14GAPDHCNR2RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |