Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13236553 | 0.80 | ABCB1 (0.48) | ALDH1A1ALOX15ABCB1LMNAADORA3 | |
| SCHEMBL3528080 | 0.78 | ALDH1A1 (0.60) | ALDH1A1ALOX15BCHEPTGS2LMNA | |
| SCHEMBL3527212 | 0.74 | ALDH1A1 (0.51) | ALDH1A1ALOX15BCHEPTGS2LMNA | |
| SCHEMBL200546 | 0.70 | ABCB1 (0.49) | ALDH1A1ALOX15ABCB1TSHR | |
| SCHEMBL13467426 | 0.69 | ALDH1A1 (0.60) | ALDH1A1ALOX15BCHEPTGS2ABCB1 | |
| SCHEMBL2353865 | 0.68 | ABCB1 (0.47) | ABCB1KDM4E | |
| SCHEMBL14087720 | 0.67 | ALDH1A1 (0.54) | ALDH1A1ALOX15BCHEPTGS2LMNA | |
| SCHEMBL14946541 | 0.65 | ALDH1A1 (0.47) | ALDH1A1ALOX15BCHEPTGS2LMNA | |
| SCHEMBL12775621 | 0.65 | ALDH1A1 (0.55) | ALDH1A1ALOX15BCHEPTGS2LMNA | |
| SCHEMBL4370043 | 0.64 | BCHE (0.43) | ALDH1A1ALOX15BCHEPTGS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7759344-B2 | Bis-aryl amide derivatives and methods of use | AMGEN INC. (US) | 2010-07-20 | — | — | US | disclosed |
| US-20080234268-A1 | Bis-aryl amide derivatives and methods of use | AMGEN INC. (US) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234268-A1 | Bis-aryl amide derivatives and methods of use | MET, REL, NAT1 | ALDH1A1 271/4885ALOX15 1670/4885BCHE 190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.