Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 14/20 | 0.49 |
| ▸ | IGF1R | P08069 | 2/20 | 0.45 |
| ▸ | MET | P08581 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | MST1R | Q04912 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | FES | P07332 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | LYN | P07948 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | FGR | P09769 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2353865 | 0.89 | ABCB1 (0.47) | ABCB1IGF1RMETKDRMST1R | |
| SCHEMBL198287 | 0.83 | ABCB1 (0.44) | ABCB1IGF1RMETKDRMST1R | |
| SCHEMBL15550275 | 0.82 | ABCB1 (0.52) | ABCB1DPP4MAOAMAOBTSHR | |
| SCHEMBL198057 | 0.80 | ABCB1 (0.50) | ABCB1DPP4MAOAMAOBTSHR | |
| SCHEMBL13467426 | 0.80 | ALDH1A1 (0.60) | ABCB1IGF1RMETKDRMST1R | |
| SCHEMBL12181067 | 0.78 | MET (0.62) | ABCB1IGF1RMETKDRMST1R | |
| SCHEMBL2949349 | 0.78 | ABCB1 (0.59) | ABCB1 | |
| SCHEMBL377244 | 0.78 | ABCB1 (0.59) | ABCB1 | |
| SCHEMBL377122 | 0.78 | ABCB1 (0.59) | ABCB1 | |
| SCHEMBL2950401 | 0.77 | MET (0.53) | ABCB1IGF1RMETKDRMST1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609100-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-24 | — | — | EP | claimed |
| US-9006440-B2 | Furopyridine derivatives | MERCK PATENT GMBH (DE) | 2015-04-14 | — | — | US | claimed |
| US-20130225569-A1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-08-29 | — | — | US | claimed |
| EP-2609100-A2 | FUROPYRIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-07-03 | — | — | EP | claimed |
| WO-2012025187-A2 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | claimed |
| US-20240293386-A1 | NOVEL COMPOUND AS PROTEIN KINASE INHIBITOR | LG CHEM, LTD. (KR) | 2024-09-05 | — | — | US | disclosed |
| WO-2024134514-A1 | NOVEL COMPOUND AS RON INHIBITOR | 주식회사 엘지화학 | 2024-06-27 | — | — | WO | disclosed |
| US-20240150325-A1 | NOVEL COMPOUND AS PROTEIN KINASE INHIBITORS | LG CHEM, LTD. (KR) | 2024-05-09 | — | — | US | disclosed |
| EP-4332106-A1 | NOVEL COMPOUND AS PROTEIN KINASE INHIBITOR | LG Chem, Ltd. (KR) | 2024-03-06 | — | — | EP | disclosed |
| CN-117355533-A | Novel compounds as protein kinase inhibitors | 株式会社LG化学 | 2024-01-05 | — | — | CN | disclosed |
| EP-4273140-A1 | NOVEL COMPOUND AS PROTEIN KINASE INHIBITOR | Lg Chem, Ltd. (KR) | 2023-11-08 | — | — | EP | disclosed |
| CN-116745279-A | Novel compounds as protein kinase inhibitors | 株式会社LG化学 | 2023-09-12 | — | — | CN | disclosed |
| US-20080312232-A1 | Substituted amide derivatives and methods of use | AMGEN INC. (US) | 2008-12-18 | — | — | US | disclosed |
| US-20080234268-A1 | Bis-aryl amide derivatives and methods of use | AMGEN INC. (US) | 2008-09-25 | — | — | US | disclosed |
| US-20080234268-A1 | Bis-aryl amide derivatives and methods of use | AMGEN INC. (US) | 2008-09-25 | — | — | US | disclosed |
| US-20080234268-A1 | Bis-aryl amide derivatives and methods of use | AMGEN INC. (US) | 2008-09-25 | — | — | US | disclosed |
| WO-2008086014-A2 | BIS-ARYL AMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008086014-A2 | BIS-ARYL AMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2008-07-17 | — | — | WO | disclosed |
| EP-1881976-A1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Amgen Inc., (US) | 2008-01-30 | — | — | EP | disclosed |
| WO-2006116713-A1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | AMGEN INC. (US) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240150325-A1 | NOVEL COMPOUND AS PROTEIN KINASE INHIBITORS | MAP3K20, SBK3, MAPKAPK2 | ABCB1 3308/4885IGF1R 1036/4885MET 686/4885 |
| US-20080312232-A1 | Substituted amide derivatives and methods of use | HGF, HGFAC, MET | ABCB1 455/4885IGF1R 57/4885MET 3/4885 |
| US-20130225569-A1 | FUROPYRIDINE DERIVATIVES | SYK, FCGRT, SSB | ABCB1 700/4885IGF1R 204/4885MET 1482/4885 |
| US-20240293386-A1 | NOVEL COMPOUND AS PROTEIN KINASE INHIBITOR | MAP3K20, SBK3, MAPKAPK2 | ABCB1 3631/4885IGF1R 1075/4885MET 657/4885 |
| US-20080234268-A1 | Bis-aryl amide derivatives and methods of use | MET, REL, NAT1 | ABCB1 104/4885IGF1R 216/4885MET 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.