Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 13/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.45 |
| ▸ | SMAD2 | Q15796 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | QPCT | Q16769 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13217779 | 0.81 | TGFBR1 (0.62) | TGFBR1BMPR1ASMAD2 | |
| SCHEMBL13218300 | 0.79 | TGFBR1 (0.50) | TGFBR1 | |
| SCHEMBL13237158 | 0.78 | TGFBR1 (0.68) | TGFBR1DYRK1ABMPR1ASMAD2 | |
| SCHEMBL18004102 | 0.74 | NPC1 (0.56) | TGFBR1DYRK1AAPPRIPK1PIK3CA | |
| SCHEMBL13217772 | 0.74 | NPC1 (0.39) | TGFBR1DYRK1AAPPRIPK1MEN1 | |
| SCHEMBL31214345 | 0.74 | DYRK1A (0.72) | TGFBR1DYRK1ABMPR1ASMAD2APP | |
| SCHEMBL26123540 | 0.73 | MAPT (0.53) | APPMEN1POLBKMT2A | |
| SCHEMBL13217774 | 0.71 | RAB9A (0.51) | MEN1NPC1POLBRAB9AKMT2A | |
| SCHEMBL10916295 | 0.70 | KDM4E (0.49) | QPCTMEN1NPC1POLBRAB9A | |
| SCHEMBL18725061 | 0.70 | QPCT (0.38) | QPCTMEN1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216787-A1 | THIAZOLE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2010-08-26 | — | — | US | disclosed |
| US-7678810-B2 | Thiazole derivative | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2010-03-16 | — | — | US | disclosed |
| US-20070154428-A1 | Thiazole derivative | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216787-A1 | THIAZOLE DERIVATIVE | TGFBR1, TGFBR2, SMAD3 | TGFBR1 1/4885DYRK1A 2191/4885BMPR1A 55/4885 |
| US-20070154428-A1 | Thiazole derivative | TGFBR1, TGFBR2, SMAD3 | TGFBR1 1/4885DYRK1A 2191/4885BMPR1A 55/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.