Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31043960 | 0.81 | RAB9A (0.49) | NPC1RAB9AHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL12597232 | 0.81 | RAB9A (0.60) | NPC1RAB9AHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL10284724 | 0.81 | SMO (0.46) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL602528 | 0.78 | HPGD (0.55) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL4191953 | 0.77 | KMT2A (0.40) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL13218158 | 0.77 | NPSR1 (0.55) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL16020967 | 0.76 | MTNR1A (0.42) | POLBTSHRUSP2PTGER1MTNR1A | |
| SCHEMBL19224717 | 0.75 | NPC1 (0.51) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL16020925 | 0.74 | HPGD (0.44) | NPC1RAB9AHPGDSMN1; SMN2TP53 | |
| SCHEMBL14005990 | 0.74 | TSHR (0.44) | HPGDL3MBTL1POLBTSHRALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2774928-B1 | POLYCYCLIC PYRIDONE DERIVATIVE HAVING INTEGRASE-INHIBITING ACTIVITY | SHIONOGI & CO (JP) | 2017-08-30 | — | — | EP | disclosed |
| US-9200009-B2 | Polycyclic pyridone derivative having integrase inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2015-12-01 | — | — | US | disclosed |
| US-20140256937-A1 | POLYCYCLIC PYRIDONE DERIVATIVE HAVING INTEGRASE INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2014-09-11 | — | — | US | disclosed |
| US-20100204237-A1 | Hydroxypyrimidinone derivatives having inhibitory activity against HIV integrase | MIKAMIYAMA HIDENORI | 2010-08-12 | — | — | US | disclosed |
| US-7745453-B2 | Hydroxypyrimidinone derivatives having inhibitory activity against HIV integrase | SHIONOGI & CO., LTD. (JP) | 2010-06-29 | — | — | US | disclosed |
| US-20070149556-A1 | Hydroxypyrimidinone derivatives having inhibitory activity against hiv integrase | SHIONOGI & CO., LTD. (JP) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149556-A1 | Hydroxypyrimidinone derivatives having inhibitory activity against hiv integrase | HAT1, SULT1A1, CDK20 | NPC1 1851/4885RAB9A 2719/4885HPGD 844/4885 |
| US-20100204237-A1 | Hydroxypyrimidinone derivatives having inhibitory activity against HIV integrase | HAT1, SULT1A1, CDK20 | NPC1 1851/4885RAB9A 2719/4885HPGD 844/4885 |
| US-20140256937-A1 | POLYCYCLIC PYRIDONE DERIVATIVE HAVING INTEGRASE INHIBITORY ACTIVITY | TYMP, CDK6, IMPA1 | NPC1 3577/4885RAB9A 4533/4885HPGD 924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.