Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | FPR3 | P25089 | 1/20 | 0.52 |
| ▸ | HTR1D | P28221 | 1/20 | 0.52 |
| ▸ | HTR1B | P28222 | 1/20 | 0.52 |
| ▸ | GPR183 | P32249 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1322887 | 0.92 | HTR1A (0.52) | HTR1ASLC6A2SLC6A3SLC6A4ADRA2A | |
| SCHEMBL1323806 | 0.85 | HTR1A (0.54) | HTR1ASLC6A2SLC6A3SLC6A4ADRA2A | |
| SCHEMBL1323840 | 0.85 | HTR1A (0.56) | HTR1ASLC6A2SLC6A3SLC6A4ADRA2A | |
| SCHEMBL1324173 | 0.85 | HTR1A (0.54) | HTR1ASLC6A2SLC6A3SLC6A4ADRA2A | |
| SCHEMBL1323756 | 0.84 | HTR1A (0.70) | HTR1ASLC6A2SLC6A3SLC6A4ADRA2A | |
| SCHEMBL12121308 | 0.84 | HTR1A (0.52) | HTR1ASLC6A2SLC6A3SLC6A4ADRA2A | |
| SCHEMBL1323787 | 0.82 | HTR1A (0.53) | HTR1ASLC6A2SLC6A3SLC6A4ADRA2A | |
| SCHEMBL12121287 | 0.82 | HTR1A (0.51) | HTR1ASLC6A2SLC6A3SLC6A4ADRA2A | |
| SCHEMBL1406042 | 0.81 | HTR1A (0.57) | HTR1ASLC6A2SLC6A3SLC6A4ADRA2A | |
| SCHEMBL1323768 | 0.78 | SLC6A2 (0.65) | HTR1ASLC6A2SLC6A3SLC6A4ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058277-B2 | Substituted indoles | MERCK PATENT GMBH (DE) | 2011-11-15 | — | — | US | claimed |
| EP-1497279-B1 | SUBSTITUTED INDOLES AND THEIR USE AS 5HT-REUPTAKE INHIBITORS AND AS 5HT LIGANDS | MERCK PATENT GMBH (DE) | 2011-03-09 | — | — | EP | claimed |
| US-20090054459-A1 | Substituted indoles | SCHADT OLIVER | 2009-02-26 | — | — | US | claimed |
| US-20050153980-A1 | Substituted indoles | MERCK PATENT GMBH (DE) | 2005-07-14 | — | — | US | claimed |
| US-7572796-B2 | Substituted indoles | MERCK PATENT GMBH (DE) | 2009-08-11 | — | — | US | disclosed |
| US-20050153980-A1 | Substituted indoles | MERCK PATENT GMBH (DE) | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054459-A1 | Substituted indoles | TPH2, TPH1, HTR1A | HTR1A 3/4885SLC6A2 30/4885SLC6A3 51/4885 |
| US-20050153980-A1 | Substituted indoles | TPH2, TPH1, HTR1A | HTR1A 3/4885SLC6A2 31/4885SLC6A3 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.