Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | PPOX | P50336 | 1/20 | 0.33 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2954267 | 1.00 | ALDH1A1 (0.41) | ALDH1A1RAB9AHSD17B10CYP11B1CYP11B2 | |
| SCHEMBL3839962 | 0.83 | ALDH1A1 (0.42) | ALDH1A1RAB9AHSD17B10CYP11B1CYP11B2 | |
| SCHEMBL2262138 | 0.82 | SMN1; SMN2 (0.40) | ALDH1A1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL14696426 | 0.81 | CA9 (0.43) | ALDH1A1RAB9AHSD17B10ALOX15HPGD | |
| SCHEMBL20367014 | 0.78 | MEN1 (0.51) | ALDH1A1RAB9AHSD17B10MEN1KMT2A | |
| SCHEMBL4466267 | 0.73 | LMNA (0.41) | ALDH1A1RAB9AHSD17B10CYP11B1CYP11B2 | |
| SCHEMBL9188549 | 0.71 | HPGD (0.42) | ALDH1A1RAB9AHSD17B10CYP11B1CYP11B2 | |
| SCHEMBL7439509 | 0.70 | RAB9A (0.67) | ALDH1A1RAB9AHSD17B10CYP11B1CYP11B2 | |
| SCHEMBL14911495 | 0.70 | HTR2B (0.40) | ALDH1A1RAB9AHSD17B10HTR2BMEN1 | |
| SCHEMBL30430382 | 0.70 | HTR2B (0.40) | ALDH1A1RAB9AHSD17B10HTR2BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856058-B1 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2014-09-03 | — | — | EP | disclosed |
| US-7759337-B2 | Phthalazine compounds and methods of use | AMGEN INC. (US) | 2010-07-20 | — | — | US | disclosed |
| US-7759337-B2 | Phthalazine compounds and methods of use | AMGEN INC. (US) | 2010-07-20 | — | — | US | disclosed |