Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.45 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.45 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GPR183 | P32249 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17098969 | 0.90 | GAA (0.60) | HPGDGAALMNAL3MBTL1PDK2 | |
| SCHEMBL5200455 | 0.82 | ALDH1A1 (0.54) | HPGDGAALMNAL3MBTL1CES2 | |
| SCHEMBL4627212 | 0.82 | PDK2 (0.72) | PDK2PDK1PDK3PDK4 | |
| SCHEMBL4627214 | 0.82 | PDK2 (0.72) | PDK2PDK1PDK3PDK4 | |
| SCHEMBL3888129 | 0.81 | SLC6A7 (0.57) | HPGDGAAPOLBKMT2AMGLL | |
| SCHEMBL3901950 | 0.81 | GAA (0.51) | HPGDGAACES2CES1PDK2 | |
| SCHEMBL252505 | 0.80 | ACHE (0.55) | HPGDGAAL3MBTL1CHRNA7 | |
| SCHEMBL788241 | 0.80 | GAA (0.84) | HPGDGAALMNAL3MBTL3L3MBTL1 | |
| SCHEMBL20788400 | 0.80 | HPGD (0.51) | HPGDLMNAPOLBL3MBTL3L3MBTL1 | |
| SCHEMBL20788402 | 0.80 | HPGD (0.51) | HPGDLMNAPOLBL3MBTL3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010088408-A2 | SUBUNIT SELECTIVE NMDA RECEPTOR ANTAGONISTS FOR THE TREATMENT OF NEUROLOGICAL CONDITIONS | EMORY UNIVERSITY (US) | 2010-08-05 | — | — | WO | disclosed |