SCHEMBL13243643

SCHEMBL13243643

C/C=C/c1c(N)ncnc1Cl

nearest known ligand 0.36

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 1/20 0.36
HTT P42858 1/20 0.32
GALR3 O60755 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2998785 0.79 NFE2L2 (0.39) NFE2L2HTT
SCHEMBL2998788 0.79 NFE2L2 (0.39) NFE2L2HTT
SCHEMBL13625315 0.78 NOS2 (0.33)
SCHEMBL21615529 0.78 NFE2L2 (0.33) NFE2L2
SCHEMBL12775976 0.77 NFE2L2 (0.35) NFE2L2HTT
SCHEMBL9942225 0.75 HTT (0.34) NFE2L2HTT
SCHEMBL678617 0.75 EGFR (0.36) NFE2L2HTT
SCHEMBL14414777 0.75 HTT (0.34) NFE2L2HTT
SCHEMBL29253838 0.74 L3MBTL1 (0.38) NFE2L2
SCHEMBL19373816 0.73 EGFR (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9908888-B2 Processes for preparing pyrazolyl-substituted pyrrolo[2,3-d]pyrimidines INCYTE CORPORATION (US) 2018-03-06 US disclosed
US-20160257687-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS INCYTE CORPORATION 2016-09-08 US disclosed
US-9290506-B2 Processes for preparing JAK inhibitors and related intermediate compounds INCYTE CORPORATION (US) 2016-03-22 US disclosed
US-20150218174-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS INCYTE CORPORATION (US) 2015-08-06 US disclosed
US-9000161-B2 Processes for preparing JAK inhibitors and related intermediate compounds INCYTE CORPORATION (US) 2015-04-07 US disclosed
US-8993582-B2 Processes for preparing JAK inhibitors and related intermediate compounds INCYTE CORPORATION (US) 2015-03-31 US disclosed
US-8883806-B2 Processes for preparing JAK inhibitors and related intermediate compounds INCYTE CORPORATION (US) 2014-11-11 US disclosed
US-20130253191-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS INCYTE CORPORATION (US) 2013-09-26 US disclosed
US-20130253193-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS INCYTE CORPORATION (US) 2013-09-26 US disclosed
US-20130253190-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS INCYTE CORPORATION (US) 2013-09-26 US disclosed
US-8410265-B2 Processes for preparing JAK inhibitors and related intermediate compounds INCYTE CORPORATION (US) 2013-04-02 US disclosed
US-20100190981-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS INCYTE CORPORATION 2010-07-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130253193-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS JAK3, JAK1, JAK2 NFE2L2 2937/4885HTT 4421/4885GALR3 4242/4885
US-20160257687-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS JAK3, JAK1, JAK2 NFE2L2 2937/4885HTT 4421/4885GALR3 4242/4885
US-20150218174-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS JAK3, JAK1, JAK2 NFE2L2 2937/4885HTT 4421/4885GALR3 4242/4885
US-20130253190-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS JAK3, JAK1, JAK2 NFE2L2 2937/4885HTT 4421/4885GALR3 4242/4885
US-20100190981-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS JAK3, JAK1, JAK2 NFE2L2 2937/4885HTT 4421/4885GALR3 4242/4885
US-20130253191-A1 PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS JAK3, JAK1, JAK2 NFE2L2 2937/4885HTT 4421/4885GALR3 4242/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.