Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1324832 | 0.87 | PDE4B (0.39) | PDE4BSCN9ACREBBPPDE4APDE4C | |
| SCHEMBL1324522 | 0.86 | KDM4C (0.43) | ALDH1A1KDM4ESMN1; SMN2PDE4BNR4A2 | |
| SCHEMBL1325440 | 0.85 | TRPM8 (0.45) | PDE4BSCN9APDE4APDE4CPDE4D | |
| SCHEMBL12285065 | 0.84 | GRIN2B (0.35) | ALDH1A1KDM4EMAPK1PDE4BSCN9A | |
| SCHEMBL1325630 | 0.80 | LCK (0.43) | MAPK14ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL18816898 | 0.79 | CSNK1D (0.39) | MAPK14ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL1325638 | 0.78 | MAPK14 (0.39) | MAPK14ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL1325693 | 0.77 | ALDH1A1 (0.40) | MAPK14ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL1325820 | 0.74 | PTGS2 (0.33) | ALDH1A1KDM4EMAPK1PDE4BGRIN2B | |
| SCHEMBL1325258 | 0.72 | MAPK14 (0.44) | MAPK14ALDH1A1KDM4EHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9193721-B2 | Fused derivatives as PI3Kδ inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2015-11-24 | — | — | US | disclosed |
| US-9193721-B2 | Fused derivatives as PI3Kδ inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2015-11-24 | — | — | US | disclosed |
| US-9193721-B2 | Fused derivatives as PI3Kδ inhibitors | INCYTE HOLDINGS CORPORATION (US) | 2015-11-24 | — | — | US | disclosed |
| EP-2558463-A1 | FUSED DERIVATIVES AS I3 INHIBITORS | Incyte Corporation (US) | 2013-02-20 | — | — | EP | disclosed |
| US-20110281884-A1 | FUSED DERIVATIVES AS PI3KDELTA INHIBITORS | INCYTE CORPORATION | 2011-11-17 | — | — | US | disclosed |
| US-20110281884-A1 | FUSED DERIVATIVES AS PI3KDELTA INHIBITORS | INCYTE CORPORATION | 2011-11-17 | — | — | US | disclosed |
| WO-2011130342-A1 | FUSED DERIVATIVES AS ΡI3Κδ INHIBITORS | INCYTE CORPORATION (US) | 2011-10-20 | — | — | WO | disclosed |
| WO-2011130342-A1 | FUSED DERIVATIVES AS ΡI3Κδ INHIBITORS | INCYTE CORPORATION (US) | 2011-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281884-A1 | FUSED DERIVATIVES AS PI3KDELTA INHIBITORS | PIK3CD, PIK3CA, PIK3CB | MAPK14 603/4885ALDH1A1 4465/4885KDM4E 2751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.