Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.36 |
| ▸ | PDCD4 | Q53EL6 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL491943 | 0.84 | KDM4E (0.50) | LMNAKDM4EALDH1A1TARBP2PDCD4 | |
| SCHEMBL4304519 | 0.84 | LMNA (0.43) | LMNACYP1A2KDM4EALDH1A1HPGD | |
| SCHEMBL14492918 | 0.80 | KDM4E (0.42) | LMNACYP1A2KDM4EAKR1B1ALDH1A1 | |
| SCHEMBL492496 | 0.78 | AKR1B1 (0.54) | CYP1A2KDM4EAKR1B1ALDH1A1HTT | |
| SCHEMBL492601 | 0.77 | LMNA (0.46) | LMNACYP1A2KDM4EAKR1B1ALDH1A1 | |
| SCHEMBL492231 | 0.77 | TBK1 (0.48) | LMNAKDM4EALDH1A1POLBTARBP2 | |
| SCHEMBL6833807 | 0.77 | ALDH1A1 (0.50) | KDM4EALDH1A1TARBP2HPGDGAA | |
| SCHEMBL8226588 | 0.77 | HTT (0.50) | LMNAKDM4EALDH1A1HTTMLYCD | |
| SCHEMBL1324010 | 0.77 | MAOB (0.56) | ALDH1A1HPGDMAOBMAPT | |
| SCHEMBL1325247 | 0.74 | PTGS2 (0.46) | LMNASLC2A1ALDH1A1TDP2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058276-B2 | Heterobicyclic carboxamides as inhibitors for kinases | NOVARTIS AG (CH) | 2011-11-15 | — | — | US | disclosed |
| US-20090030009-A1 | Heterobicyclic Carboxamides as Inhibitors for Kinases | NOVARTIS AG (CH) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030009-A1 | Heterobicyclic Carboxamides as Inhibitors for Kinases | PHKG1, MAP3K20, CDK2 | LMNA 2623/4885CYP1A2 2732/4885SLC2A1 4297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.