Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13255419 | 0.91 | MEN1 (0.41) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL13255602 | 0.91 | MAPT (0.42) | MAPTALDH1A1KDM4ENPSR1GAA | |
| SCHEMBL13850822 | 0.91 | GRM2 (0.42) | MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL13255605 | 0.89 | MEN1 (0.38) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL13255533 | 0.89 | PDE3B (0.46) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL13255400 | 0.88 | MEN1 (0.40) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL13255515 | 0.88 | MEN1 (0.40) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL3877680 | 0.88 | MAPT (0.40) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL13255611 | 0.88 | GRM2 (0.39) | KDM4ENPSR1GAASMN1; SMN2 | |
| SCHEMBL13255620 | 0.87 | LMNA (0.40) | ALDH1A1L3MBTL1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7759372-B2 | Nitrogen-containing heteroaryl compounds having inhibitory activity against HIV integrase | SHIONOGI & CO., LTD. (JP) | 2010-07-20 | — | — | US | disclosed |