Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8201163 | 0.77 | ADRA2A (0.46) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL16838683 | 0.77 | ADRA2A (0.46) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL5975716 | 0.77 | ADRA2A (0.46) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL8643386 | 0.77 | DPP4 (0.50) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL12729962 | 0.77 | DPP4 (0.50) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL13255670 | 0.76 | HPGD (0.53) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL2756152 | 0.76 | HPGD (0.53) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL3262994 | 0.75 | DPP4 (0.48) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL12937983 | 0.74 | LMNA (0.48) | ADRA2AADRA2CLMNAHIF1AKDM4E | |
| SCHEMBL16488395 | 0.74 | LMNA (0.45) | ADRA2AADRA2CLMNAHIF1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010096462-A1 | LINKED DIIMIDAZOLE DERIVATIVES | ENANTA PHARMACEUTICALS, INC (US) | 2010-08-26 | — | — | WO | disclosed |
| WO-2010091413-A1 | LINKED DIBENZIMIDAZOLE DERIVATIVES | ENANTA PHARMACEUTICALS, INC. (US) | 2010-08-12 | — | — | WO | disclosed |