Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2355814 | 0.86 | CASP1 (0.46) | CASP1KDM4ETSHRPTGS1HDAC4 | |
| SCHEMBL25722842 | 0.79 | HDAC4 (0.57) | CASP1KDM4ETSHRPTGS1HDAC4 | |
| SCHEMBL13160048 | 0.79 | AR (0.48) | CASP1KDM4ETSHRPTGS1HDAC4 | |
| SCHEMBL13255810 | 0.79 | CASP1 (0.46) | CASP1KDM4ETSHRPTGS1HDAC4 | |
| SCHEMBL11746489 | 0.79 | ALDH1A1 (0.60) | KDM4EARSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14266924 | 0.79 | AR (0.48) | KDM4EARSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11422056 | 0.78 | CASP1 (0.45) | CASP1KDM4ETSHRPTGS1HDAC4 | |
| SCHEMBL327806 | 0.77 | SLC6A4 (0.63) | ARSLC6A2SLC6A4SLC6A3RIPK1 | |
| SCHEMBL11063307 | 0.77 | PTGS1 (0.56) | CASP1KDM4ETSHRPTGS1HDAC4 | |
| SCHEMBL30345552 | 0.77 | PTGS1 (0.56) | CASP1KDM4ETSHRPTGS1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010096462-A1 | LINKED DIIMIDAZOLE DERIVATIVES | ENANTA PHARMACEUTICALS, INC (US) | 2010-08-26 | — | — | WO | disclosed |