Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 6/20 | 0.40 |
| ▸ | AGXT | P21549 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13256337 | 0.85 | IDO1 (0.50) | IDO1HTTBACE1KDM4EMAPT | |
| SCHEMBL3769133 | 0.82 | IDO1 (0.59) | IDO1AGXTHTTALDH1A1BACE1 | |
| SCHEMBL27984974 | 0.76 | IDO1 (0.50) | IDO1AGXTMAPK8ALDH1A1BACE1 | |
| Hydrochloric Acid SCHEMBL3393428 | 0.75 | IDO1 (0.41) | IDO1AGXTMAPK8HTTALDH1A1 | |
| SCHEMBL13256355 | 0.73 | BACE1 (0.54) | IDO1ALDH1A1BACE1KDM4EMAPT | |
| SCHEMBL13256341 | 0.73 | IDO1 (0.69) | IDO1HTTALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL538102 | 0.71 | IDO1 (0.47) | IDO1AGXTMAPK8AURKARPS6KB1 | |
| SCHEMBL13256352 | 0.71 | IDO1 (0.51) | IDO1ALDH1A1BACE1MAPTALDH3A1 | |
| SCHEMBL13256348 | 0.71 | BACE1 (0.71) | IDO1HTTALDH1A1BACE1KDM4E | |
| SCHEMBL22275619 | 0.70 | IDO1 (0.61) | IDO1HTTALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100184851-A1 | INHIBITION OF CELL PROLIFERATION | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-07-22 | — | — | US | disclosed |
| US-20100184851-A1 | INHIBITION OF CELL PROLIFERATION | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-07-22 | — | — | US | disclosed |
| WO-2010025448-A2 | INHIBITION OF CELL PROLIFERATION | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184851-A1 | INHIBITION OF CELL PROLIFERATION | MKI67, RB1, RAF1 | IDO1 4276/4885AGXT 4295/4885MAPK8 532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.